“Mean doesn't last. Mean is over fast. Maybe this is the essence of eve...” — Christopher Guest Quote

“Mean doesn't last. Mean is over fast. Maybe this is the essence of everything, which is, to me, if there is no emotional center for what I'm doing, I have no interest in it at all.”

“In 'Waiting for Guffman,' the character I played, the Corky character, he's very serious about what he does, and it's not meant to be mean that this is a small town and these people aren't the most talented people. They're trying the best they can. So to be mean, that would be kind of horrifying in its superficiality.”

“Now, as the world's scientists focus with increasing intensity on transforming the genetic codes of every living creature into information that can be used to treat and ultimately prevent disease, Shenzhen is home to a different kind of factory: B.G.I., formerly called Beijing Genomics Institute, the world's largest genetic-research center.”

“When I show up in New York, and I look at the skyline, it's like showing up in a mountain range. My gaze goes toward the most impressive-looking climb. It's always gone to the top of the World Trade Center.”